Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.40 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.39 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 6/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3112178 | 0.94 | ACKR3 (0.41) | BRD4PLK1PLK3PLK2ACKR3 | |
| SCHEMBL3107180 | 0.94 | ACKR3 (0.41) | BRD4PLK1PLK3PLK2ACKR3 | |
| SCHEMBL5246436 | 0.94 | ACKR3 (0.44) | PLK1PLK3PLK2ACKR3CNR2 | |
| SCHEMBL3110327 | 0.94 | ACKR3 (0.42) | BRD4PLK1PLK3PLK2ACKR3 | |
| SCHEMBL5247636 | 0.91 | ACKR3 (0.38) | BRD4PLK1PLK3PLK2ACKR3 | |
| SCHEMBL3110965 | 0.89 | ACKR3 (0.43) | BRD4PLK1PLK3PLK2ACKR3 | |
| SCHEMBL5250118 | 0.88 | BRD4 (0.43) | BRD4PLK1PLK3PLK2ACKR3 | |
| SCHEMBL3106830 | 0.87 | MAPK14 (0.45) | ACKR3CNR2 | |
| SCHEMBL3114010 | 0.87 | CNR2 (0.40) | BRD4PLK1PLK3PLK2ACKR3 | |
| SCHEMBL3113338 | 0.87 | SMPD1 (0.43) | BRD4PLK1PLK3PLK2ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867331-A1 | TRIAZOLE DERIVATIVE AND THE USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2007-12-19 | — | — | EP | disclosed |