Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 20/20 | 0.74 |
| ▸ | HTR2C | P28335 | 18/20 | 0.74 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243677 | 0.95 | HTR2A (0.73) | HTR2AHTR2CKCNH2 | |
| SCHEMBL5244501 | 0.94 | HTR2A (0.72) | HTR2AHTR2CKCNH2 | |
| SCHEMBL5245454 | 0.92 | HTR2A (0.71) | HTR2AHTR2C | |
| SCHEMBL1167154 | 0.87 | HTR2A (0.68) | HTR2AHTR2CKCNH2 | |
| SCHEMBL1166048 | 0.87 | HTR2A (0.68) | HTR2AHTR2CKCNH2 | |
| SCHEMBL1165512 | 0.86 | HTR2A (0.77) | HTR2AHTR2CKCNH2 | |
| SCHEMBL5243451 | 0.86 | HTR2A (0.68) | HTR2AHTR2CKCNH2 | |
| SCHEMBL1165470 | 0.86 | HTR2A (0.84) | HTR2AHTR2CKCNH2 | |
| SCHEMBL1165907 | 0.86 | HTR2A (0.70) | HTR2AHTR2C | |
| SCHEMBL1166005 | 0.86 | HTR2A (0.81) | HTR2AHTR2CKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833799-A2 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT-2a SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2007-09-19 | — | — | EP | claimed |
| WO-2006055734-A2 | 3-PHENYL-PYRAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2006-05-26 | — | — | WO | claimed |