Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5243487 | 0.91 | PDE5A (0.40) | PDE5AKCNH2WNT1GSK3BDYRK1A | |
| SCHEMBL5308254 | 0.90 | PDE5A (0.45) | PDE5AKCNH2 | |
| SCHEMBL5247188 | 0.87 | PDE5A (0.58) | PDE5AKCNH2 | |
| SCHEMBL5243623 | 0.85 | PDE5A (0.50) | PDE5AKCNH2 | |
| SCHEMBL5248503 | 0.80 | PDE5A (0.46) | PDE5AKCNH2 | |
| SCHEMBL5246797 | 0.80 | PDE5A (0.46) | PDE5AKCNH2GSK3B | |
| SCHEMBL5245813 | 0.79 | PDE5A (0.52) | PDE5AKCNH2 | |
| SCHEMBL5247971 | 0.79 | PDE5A (0.53) | PDE5AKCNH2 | |
| SCHEMBL5287973 | 0.77 | PDE5A (0.61) | PDE5AKCNH2 | |
| SCHEMBL5293257 | 0.77 | PDE5A (0.58) | PDE5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809632-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006046135-A2 | PYRAZOLO[4,3-D] PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-05-04 | — | — | WO | disclosed |