Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.53 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 4/20 | 0.33 |
| ▸ | PPARD | Q03181 | 4/20 | 0.33 |
| ▸ | PPARA | Q07869 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2022261 | 0.87 | GRM2 (0.55) | GRM2HTR2CCHRM5GRIN2BHCRTR1 | |
| SCHEMBL2023783 | 0.80 | GRM2 (0.51) | GRM2HTR2CCHRM5GRIN2BHCRTR1 | |
| SCHEMBL27703750 | 0.80 | HTR2C (0.36) | GRM2HTR2CCHRM5HCRTR1HCRTR2 | |
| SCHEMBL2023969 | 0.80 | GRM2 (0.57) | GRM2HTR2CCHRM5GRIN2BHCRTR1 | |
| SCHEMBL2026779 | 0.80 | GRM2 (0.57) | GRM2HTR2CCHRM5GRIN2BHCRTR1 | |
| SCHEMBL8270181 | 0.80 | GRM2 (0.57) | GRM2HTR2CCHRM5GRIN2BHCRTR1 | |
| SCHEMBL2027849 | 0.79 | GRM2 (0.60) | GRM2HTR2CCHRM5GRIN2BPIK3CG | |
| SCHEMBL12580820 | 0.79 | GRM2 (0.56) | GRM2HTR2CCHRM5GRIN2BHCRTR1 | |
| SCHEMBL2025995 | 0.78 | GRM2 (0.55) | GRM2HTR2CCHRM5GRIN2BHCRTR1 | |
| SCHEMBL12442033 | 0.78 | GRM2 (0.53) | GRM2HTR2CCHRM5GRIN2BHCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778634-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | AstraZeneca AB (SE) | 2007-05-02 | — | — | EP | claimed |
| WO-2006020879-A1 | ISOINDOLONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | claimed |