Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 7/20 | 0.37 |
| ▸ | CNR2 | P34972 | 6/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL52175 | 0.87 | KCNH2 (0.50) | KCNH2CYP2C9MAPK1LMNA | |
| SCHEMBL51888 | 0.82 | KCNH2 (0.51) | KCNH2CYP2C9MAPK1LMNA | |
| SCHEMBL52217 | 0.80 | KCNH2 (0.52) | KCNH2CYP2C9MAPK1LMNA | |
| SCHEMBL5534536 | 0.76 | KCNH2 (0.42) | KCNH2CYP2C9DGAT1CNR1CNR2 | |
| SCHEMBL5539660 | 0.76 | KCNH2 (0.42) | KCNH2CYP2C9MMP13DGAT1CNR2 | |
| SCHEMBL5538310 | 0.75 | KCNH2 (0.39) | KCNH2CYP2C9MMP13DGAT1CNR2 | |
| SCHEMBL52498 | 0.74 | CYP2C9 (0.47) | KCNH2CYP2C9MMP13DGAT1CNR2 | |
| SCHEMBL13917332 | 0.74 | KCNH2 (0.47) | KCNH2CYP2C9MMP13DGAT1CNR2 | |
| SCHEMBL5540973 | 0.73 | KCNH2 (0.40) | KCNH2CYP2C9MMP13DGAT1CNR1 | |
| SCHEMBL52913 | 0.73 | CYP2C9 (0.44) | KCNH2CYP2C9MMP13DGAT1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280981-B1 | BRIDGED HETEROCYCLES AS HIV INTEGRASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2014-04-23 | — | — | EP | disclosed |
| US-8129398-B2 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-06 | — | — | US | disclosed |
| US-20090253677-A1 | HIV Integrase Inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090253677-A1 | HIV Integrase Inhibitors | DNTT, POLB, UNG | KCNH2 3969/4885CYP2C9 602/4885MMP13 4137/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.