Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 13/20 | 0.61 |
| ▸ | NR1H3 | Q13133 | 13/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.48 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27730635 | 0.82 | NR1H2 (0.47) | NR1H2NR1H3NR1I2NR3C1ALDH1A1 | |
| SCHEMBL1407223 | 0.81 | NR1H2 (0.49) | NR1H2NR1H3NR1I2NR3C1ALDH1A1 | |
| SCHEMBL31268513 | 0.77 | CYP2C9 (0.44) | NR1H2NR1H3ALDH1A1NPSR1CYP1A2 | |
| SCHEMBL1407219 | 0.76 | NR1H3 (1.00) | NR1H2NR1H3NR1I2NR3C1ALDH1A1 | |
| SCHEMBL1407111 | 0.75 | NR1H2 (0.82) | NR1H2NR1H3NR1I2NR3C1ALDH1A1 | |
| SCHEMBL1407311 | 0.75 | MAPT (0.45) | NR1H2NR1H3ALDH1A1LMNANPSR1 | |
| SCHEMBL3864397 | 0.74 | NR1H3 (0.95) | NR1H2NR1H3NR1I2NR3C1ALDH1A1 | |
| SCHEMBL1407764 | 0.74 | NR1H2 (0.77) | NR1H2NR1H3NR1I2NR3C1AR | |
| SCHEMBL1407324 | 0.72 | NR1H2 (0.75) | NR1H2NR1H3NR1I2NR3C1ALDH1A1 | |
| SCHEMBL3862965 | 0.72 | NR1H2 (0.73) | NR1H2NR1H3NR1I2NR3C1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773781-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | Wyeth (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006017384-A2 | INDAZOLES USEFUL IN TREATING CARDIOVASCULAR DISEASES | WYETH (US) | 2006-02-16 | — | — | WO | claimed |
| US-20060030612-A1 | Indazoles useful in treating cardiovascular diseases | WYETH (US) | 2006-02-09 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060030612-A1 | Indazoles useful in treating cardiovascular diseases | NR1H2, NR1H3, CYP46A1 | NR1H2 1/4885NR1H3 2/4885NR1I2 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.