SCHEMBL5248205

SCHEMBL5248205

NC(=O)Oc1cccn2cc(-c3cccc4ccccc34)nc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.40
ALDH1A3 P47895 5/20 0.40
ALDH1A2 O94788 3/20 0.40
CASP1 P29466 1/20 0.39
DHODH Q02127 1/20 0.39
KDM4E B2RXH2 4/20 0.38
RAB9A P51151 4/20 0.38
NPC1 O15118 3/20 0.38
MAPT P10636 3/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
PKM P14618 1/20 0.38
MAPK1 P28482 1/20 0.38
TUBB4A P04350 1/20 0.37
TUBB P07437 1/20 0.37
TUBA3C P0DPH7 1/20 0.37
TUBA1B P68363 1/20 0.37
TUBA4A P68366 1/20 0.37
TUBB4B P68371 1/20 0.37
TUBB3 Q13509 1/20 0.37
TUBB2A Q13885 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5248164 0.84 DHODH (0.36) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E
SCHEMBL5250303 0.84 DHODH (0.38) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E
SCHEMBL5248531 0.82 MAPT (0.61) ALDH1A1KDM4ERAB9ANPC1MAPT
SCHEMBL5073373 0.81 DHODH (0.50) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E
SCHEMBL5252624 0.81 DHODH (0.59) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E
SCHEMBL5253083 0.79 DHODH (0.64) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E
SCHEMBL5252652 0.79 DHODH (0.47) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E
SCHEMBL5250307 0.79 DHODH (0.39) ALDH1A1ALDH1A3ALDH1A2CASP1DHODH
SCHEMBL5251228 0.79 DHODH (0.53) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E
SCHEMBL5254537 0.78 DHODH (0.40) ALDH1A1ALDH1A3ALDH1A2DHODHKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1257551-B1 HETEROCYCLIC COMPOUNDS AND THEIR USE AS PARP INHIBITORS ABBOTT GMBH & CO KG (DE) 2007-09-05 EP disclosed