Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | KAT7 | O95251 | 1/20 | 0.45 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1780154 | 1.00 | PARP1 (0.50) | PARP1ACKR3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL30602886 | 0.94 | SMN1; SMN2 (0.53) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL26705305 | 0.94 | SMN1; SMN2 (0.53) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL30179036 | 0.94 | SMN1; SMN2 (0.53) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL25338897 | 0.91 | SMN1; SMN2 (0.50) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL20046470 | 0.91 | SMN1; SMN2 (0.50) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL29132380 | 0.90 | SMN1; SMN2 (0.54) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL26925080 | 0.89 | SMN1; SMN2 (0.52) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL29579133 | 0.89 | SMN1; SMN2 (0.49) | PARP1SMN1; SMN2NPC1RAB9AHTT | |
| SCHEMBL2386800 | 0.89 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9AHTTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831164-A1 | HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS | AstraZeneca AB (SE) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006067401-A1 | HETEROCYCLIC COMPOUNDS AS CCR2B ANTAGONISTS | ASTRAZENECA AB (SE) | 2006-06-29 | — | — | WO | disclosed |