Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8262538 | 0.91 | PDE5A (0.49) | PDE5AKCNH2 | |
| SCHEMBL5243922 | 0.82 | PDE5A (0.46) | PDE5AKCNH2 | |
| SCHEMBL5248453 | 0.81 | PDE5A (0.60) | PDE5AKCNH2 | |
| SCHEMBL4038530 | 0.81 | PDE5A (0.61) | PDE5AKCNH2 | |
| SCHEMBL4476229 | 0.80 | PDE5A (0.61) | PDE5AKCNH2 | |
| SCHEMBL331573 | 0.80 | PDE5A (0.52) | PDE5AKCNH2 | |
| SCHEMBL4044350 | 0.79 | PDE5A (0.63) | PDE5AKCNH2 | |
| SCHEMBL4463332 | 0.79 | PDE5A (0.46) | PDE5AKCNH2 | |
| SCHEMBL331648 | 0.78 | PDE5A (0.47) | PDE5AKCNH2 | |
| SCHEMBL331621 | 0.77 | PDE5A (0.35) | PDE5AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809632-A2 | PYRAZOLO[4,3-D]PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | Pharmacia & Upjohn Company LLC (US) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006046135-A2 | PYRAZOLO[4,3-D] PYRIMIDINE DERIVATIVES USEFUL AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-05-04 | — | — | WO | disclosed |