Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 20/20 | 0.76 |
| ▸ | TACR2 | P21452 | 1/20 | 0.55 |
| ▸ | HRH2 | P25021 | 1/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.55 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.55 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276312 | 0.89 | GNRHR (0.82) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3278718 | 0.87 | GNRHR (0.77) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3274218 | 0.86 | GNRHR (0.76) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3275214 | 0.86 | GNRHR (1.00) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3275932 | 0.86 | GNRHR (0.78) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL5307659 | 0.79 | GNRHR (0.77) | GNRHRHTR2A | |
| SCHEMBL3282272 | 0.77 | GNRHR (0.84) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3279451 | 0.77 | GNRHR (0.73) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3274286 | 0.77 | GNRHR (0.78) | GNRHRTACR2HRH2OPRM1OPRD1 | |
| SCHEMBL3274234 | 0.77 | GNRHR (0.70) | GNRHRTACR2HRH2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758895-A1 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2006009734-A1 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | WYETH (US) | 2006-01-26 | — | — | WO | disclosed |