Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 4/20 | 0.47 |
| ▸ | BTK | Q06187 | 16/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.45 |
| ▸ | LYN | P07948 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | RGS12 | O14924 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23847508 | 0.99 | TNK2 (0.48) | TNK2BTKLCKLYNKDM4E | |
| SCHEMBL8820010 | 0.90 | EGFR (0.43) | TNK2KDM4EMEN1NPC1ALDH1A1 | |
| SCHEMBL23834462 | 0.89 | BTK (0.45) | TNK2BTKLCK | |
| SCHEMBL19230428 | 0.89 | BTK (0.56) | TNK2BTKLCKSRCTEK | |
| SCHEMBL22710626 | 0.86 | BTK (0.56) | BTKLCKLYNEGFRFYN | |
| SCHEMBL23834499 | 0.86 | BTK (0.40) | TNK2BTKLCKLYNKDM4E | |
| SCHEMBL23847507 | 0.84 | BTK (0.54) | TNK2BTKLCKLYNEGFR | |
| SCHEMBL30053759 | 0.84 | BTK (0.54) | TNK2BTKLCKLYNEGFR | |
| SCHEMBL23855013 | 0.84 | BTK (0.54) | TNK2BTKLCKLYNEGFR | |
| SCHEMBL23855018 | 0.84 | BTK (0.54) | TNK2BTKLCKLYNEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268481-B1 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | ABBOTT GMBH & CO KG (DE) | 2007-12-12 | — | — | EP | disclosed |
| US-7071199-B1 | Kinase inhibitors as therapeutic agents | ABBOTT GMBH & CCO. KG (DE) | 2006-07-04 | — | — | US | disclosed |
| CN-1390220-A | Kinase inhibitors as therapeutic agents | ABBOTT AG (DE) | 2003-01-08 | — | — | CN | disclosed |