Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | GALK1 | P51570 | 1/20 | 0.43 |
| ▸ | CASP6 | P55212 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PLEC | Q15149 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5252140 | 0.81 | KDR (0.61) | KDRNR1H4HPSEKCNK3KCNK9 | |
| SCHEMBL5249171 | 0.73 | KDR (0.59) | KDRNR1H4HPSEKCNK3KCNK9 | |
| SCHEMBL5250661 | 0.71 | KDR (0.61) | KDRNR1H4HPSEKCNK3KCNK9 | |
| SCHEMBL22543145 | 0.71 | NR1H4 (0.78) | NR1H4HPSEKCNK3KCNK9PLAU | |
| SCHEMBL5253291 | 0.70 | KDR (0.48) | KDRNR1H4HPSEPLAUMAPT | |
| SCHEMBL30396799 | 0.70 | KCNK3 (0.71) | KDRNR1H4HPSEKCNK3KCNK9 | |
| SCHEMBL6710523 | 0.69 | KDR (0.51) | KDRNR1H4HPSENPC1RAB9A | |
| SCHEMBL5252137 | 0.68 | KDR (1.00) | KDRFGFR1 | |
| SCHEMBL20917283 | 0.67 | CACNA2D1 (0.58) | MAPTMAPK1MEN1KMT2ALMNA | |
| SCHEMBL14684329 | 0.67 | NR1H4 (0.71) | NR1H4HPSEKCNK3KCNK9PLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1614683-B1 | Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use | AGOURON PHARMA (US) | 2007-11-21 | — | — | EP | disclosed |