Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.77 |
| ▸ | IGF1R | P08069 | 8/20 | 0.77 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5254506 | 0.97 | MAP2K1 (0.72) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL6998163 | 0.96 | MAP2K1 (0.79) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL5255981 | 0.91 | IGF1R (0.65) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL5256771 | 0.90 | IGF1R (0.66) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL5255721 | 0.89 | IGF1R (0.65) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL5254321 | 0.88 | IGF1R (0.63) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL344875 | 0.87 | MAP2K1 (1.00) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL6993524 | 0.85 | MAP2K1 (0.76) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL4984590 | 0.85 | MAP2K1 (0.91) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 | |
| SCHEMBL6184528 | 0.85 | MAP2K1 (0.74) | MAP2K1IGF1RMAPK3MAPK1MAP3K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242382-B1 | TRICYCLIC PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-02-07 | — | — | EP | claimed |