Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 18/20 | 0.69 |
| ▸ | RAF1 | P04049 | 9/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.47 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27707570 | 0.82 | MAP2K1 (1.00) | MAP2K1RAF1MAPK13SRCMAP3K8 | |
| SCHEMBL5253113 | 0.81 | MAP2K1 (0.82) | MAP2K1RAF1MAPK13SRCMAP3K8 | |
| SCHEMBL5256805 | 0.81 | MAP2K1 (0.66) | MAP2K1RAF1SRCPRKCQ | |
| SCHEMBL6382824 | 0.81 | MAP2K1 (0.68) | MAP2K1RAF1SRCPRKCQ | |
| SCHEMBL5251382 | 0.78 | MAP2K1 (0.64) | MAP2K1RAF1MAPK13SRCMAP3K8 | |
| SCHEMBL5254322 | 0.78 | MAP2K1 (0.64) | MAP2K1RAF1MAPTMAPK13SRC | |
| SCHEMBL5256370 | 0.77 | EGFR (0.60) | SRCMAP3K8MAPK14 | |
| SCHEMBL5256236 | 0.76 | MAP2K1 (0.77) | MAP2K1RAF1MAPK13SRCMAP3K8 | |
| SCHEMBL27709831 | 0.76 | MAP2K1 (0.78) | MAP2K1RAF1MAPK13SRCMAP3K8 | |
| SCHEMBL5254847 | 0.75 | MAP2K1 (0.73) | MAP2K1RAF1MAPK13SRCMAP3K8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242382-B1 | TRICYCLIC PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-02-07 | — | — | EP | claimed |