Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 15/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5178035 | 0.88 | CHEK2 (0.67) | CHEK2KDM4EMEN1POLBCYP3A4 | |
| SCHEMBL3925642 | 0.88 | CHEK2 (0.85) | CHEK2MEN1KMT2A | |
| SCHEMBL5177920 | 0.86 | CHEK2 (0.66) | CHEK2KDM4EMEN1POLBCYP3A4 | |
| SCHEMBL5178523 | 0.85 | CHEK2 (0.52) | CHEK2KDM4EMEN1POLBCYP3A4 | |
| SCHEMBL5251053 | 0.82 | CHEK2 (0.64) | CHEK2 | |
| SCHEMBL5178851 | 0.82 | CHEK2 (0.67) | CHEK2KDM4EMEN1POLBCYP3A4 | |
| SCHEMBL5256560 | 0.82 | CHEK2 (0.66) | CHEK2 | |
| SCHEMBL5252224 | 0.82 | CHEK2 (0.69) | CHEK2MEN1KMT2A | |
| SCHEMBL5250655 | 0.82 | CHEK2 (0.65) | CHEK2MEN1KMT2A | |
| SCHEMBL5253780 | 0.82 | CHEK2 (0.65) | CHEK2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1435947-B1 | 2-PHENYL BENZIMIDAZOLES AND IMIDAZO-¬4,5|-PYRIDINES AS CDS1/CHK2-INHIBITORS AND ADJUVANTS TO CHEMOTHERAPY OR RADIATION THERAPY IN THE TREATMENT OF CANCER | ORTHO MCNEIL PHARM INC (US) | 2007-08-15 | — | — | EP | claimed |