Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.78 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.70 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190749 | 0.93 | PIK3CA (0.80) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL29439930 | 0.88 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL960078 | 0.88 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL189616 | 0.86 | PIK3CA (0.80) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL960435 | 0.85 | PIK3CA (0.95) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190347 | 0.84 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190353 | 0.83 | PIK3CA (0.76) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL959505 | 0.83 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190409 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL1181153 | 0.82 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1812446-A1 | PHARMACEUTICAL COMPOUNDS | Piramed Limited (GB) | 2007-08-01 | — | — | EP | disclosed |
| WO-2006046040-A1 | PHARMACEUTICAL COMPOUNDS | PIRAMED LIMITED (GB) | 2006-05-04 | — | — | WO | disclosed |