Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14459475 | 0.84 | MAPK14 (0.60) | MAPK14HSP90AA1MAPTRECQLKDM4E | |
| SCHEMBL5250252 | 0.82 | MAPK14 (0.66) | MAPK14HSP90AA1MAPTRECQLKDM4E | |
| SCHEMBL6298551 | 0.79 | MAPK14 (0.62) | MAPK14HSP90AA1MAPTRECQLKDM4E | |
| SCHEMBL16139183 | 0.79 | MAPK14 (0.76) | MAPK14GSK3ASRCSYK | |
| SCHEMBL6298713 | 0.79 | MAPK14 (0.61) | MAPK14HSP90AA1MAPTRECQLKDM4E | |
| SCHEMBL6299768 | 0.77 | MAPK14 (0.59) | MAPK14GSK3ASRCSYK | |
| SCHEMBL6298728 | 0.77 | MAPK14 (0.59) | MAPK14HSP90AA1GSK3ASRCSYK | |
| SCHEMBL5252206 | 0.77 | MAPK14 (0.59) | MAPK14GSK3ASRCSYK | |
| SCHEMBL5251975 | 0.77 | MAPK14 (0.61) | MAPK14GSK3ASRCSYK | |
| SCHEMBL6306257 | 0.77 | MAPK14 (0.62) | MAPK14HSP90AA1MAPTRECQLKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1232150-B1 | UREA DERIVATIVES AS ANTI-INFLAMMATORY AGENTS | BOEHRINGER INGELHEIM PHARMA (US) | 2007-10-10 | — | — | EP | disclosed |
| US-7241758-B2 | Compounds useful as anti-inflammatory agents | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2007-07-10 | — | — | US | disclosed |
| US-6492393-B1 | SUCH AS 1-(5-TERT-BUTYL-2-METHOXYPHENYL)-3-(4-(2-METHOXY-PYRIDIN-4YL-OXY)-NAPHTHALEN-1-YL)-UREA; CYTOKINE INHIBITORS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2002-12-10 | — | — | US | disclosed |