Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.64 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.59 |
| ▸ | GAK | O14976 | 2/20 | 0.59 |
| ▸ | ABL1 | P00519 | 2/20 | 0.59 |
| ▸ | LCK | P06239 | 2/20 | 0.59 |
| ▸ | MET | P08581 | 2/20 | 0.59 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.59 |
| ▸ | BLK | P51451 | 2/20 | 0.59 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.59 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.59 |
| ▸ | EPHA6 | Q9UF33 | 2/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | STK10 | O94804 | 1/20 | 0.59 |
| ▸ | LYN | P07948 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230079 | 0.90 | EGFR (0.63) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1418196 | 0.89 | EGFR (0.70) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1418194 | 0.89 | EGFR (0.70) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL3585057 | 0.89 | EGFR (0.78) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL3585054 | 0.89 | EGFR (0.78) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1191544 | 0.89 | EGFR (0.87) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL1191542 | 0.89 | EGFR (0.87) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL3589219 | 0.89 | EGFR (0.72) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL3589218 | 0.89 | EGFR (0.72) | EGFRERBB2ERBB4GAKABL1 | |
| SCHEMBL5255976 | 0.89 | EGFR (0.70) | EGFRERBB2ERBB4GAKLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1280798-B1 | BICYCLIC HETEROCYLCES, MEDICAMENTS CONTAINING SAID COMPOUNDS, THE USE THEREOF AND METHOD FOR PRODUCING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 2007-01-03 | — | — | EP | disclosed |