Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 2/20 | 0.43 |
| ▸ | CA9 | Q16790 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5001900 | 0.80 | MAPT (0.44) | CA1CA2ACHEMAPTPOLB | |
| SCHEMBL3908587 | 0.79 | CA1 (0.41) | CA1CA2ACHEMAPTPOLB | |
| SCHEMBL3916212 | 0.77 | PARP1 (0.46) | MAPTPOLBPARP1CA12CA9 | |
| SCHEMBL3648969 | 0.77 | MAPT (0.53) | MAPTPOLBATMPARP1CA12 | |
| SCHEMBL31482838 | 0.77 | MAPT (0.53) | MAPTPOLBATMPARP1CA12 | |
| SCHEMBL31482835 | 0.77 | MAPT (0.53) | MAPTPOLBATMPARP1CA12 | |
| SCHEMBL3909447 | 0.75 | MEN1 (0.59) | MAPTPOLBPARP1MEN1KMT2A | |
| SCHEMBL3651624 | 0.75 | MEN1 (0.54) | MAPTPOLBPARP1CA12CA9 | |
| SCHEMBL3650526 | 0.73 | CYP1A2 (0.52) | MAPTPOLBATMPARP1CA12 | |
| SCHEMBL3646520 | 0.72 | CNR1 (0.50) | ACHEMAPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797054-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI Pharmaceuticals, Inc. (US) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006017443-A2 | ARYL-AMINO SUBSTITUTED PYRROLOPYRIMIDINE MULTI-KINASE INHIBITING COMPOUNDS | OSI PHARMACEUTICALS, INC. (US) | 2006-02-16 | — | — | WO | disclosed |