Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCND2 | P30279 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5258365 | 0.88 | TLR8 (0.39) | TLR8CCNB2CCNE2CDK1FGFR1 | |
| SCHEMBL5253286 | 0.83 | MAPK14 (0.42) | MAPK14TLR8CCNB2CCNE2CDK1 | |
| SCHEMBL1062919 | 0.80 | MAPK14 (0.42) | MAPK14HSD11B1MAPK13MAPK12MAPK11 | |
| SCHEMBL2944615 | 0.79 | SIK1 (0.43) | MAPK14TLR8CCNB2CCNE2CDK1 | |
| SCHEMBL2941239 | 0.79 | FGFR1 (0.42) | MAPK14TLR8CCNB2CCNE2CDK1 | |
| SCHEMBL1726714 | 0.79 | CDK1 (0.41) | MAPK14TLR8CCNB2CCNE2CDK1 | |
| SCHEMBL1065189 | 0.78 | MAPK14 (0.44) | MAPK14HSD11B1MAPK13MAPK12MAPK11 | |
| SCHEMBL2945023 | 0.77 | FGFR2 (0.42) | CCNB2CCNE2CDK1FGFR1CDK4 | |
| SCHEMBL2945196 | 0.76 | MAPK14 (0.42) | MAPK14TLR8CCNB2CCNE2CDK1 | |
| SCHEMBL5253164 | 0.76 | TDP1 (0.41) | CCNB2CCNE2CDK1FGFR1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1333833-A4 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-10-24 | — | — | EP | disclosed |
| EP-1333833-A2 | NOVEL COMPOUNDS | SmithKline Beecham Corporation (US) | 2003-08-13 | — | — | EP | disclosed |
| WO-2002059083-A2 | NOVEL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-08-01 | — | — | WO | disclosed |