Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.74 |
| ▸ | EIF2AK3 | Q9NZJ5 | 3/20 | 0.74 |
| ▸ | PIM1 | P11309 | 1/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.57 |
| ▸ | IGF1R | P08069 | 12/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.49 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525543 | 1.00 | TTK (0.74) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL526621 | 0.94 | TTK (0.85) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL10092921 | 0.93 | TTK (0.70) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL525792 | 0.90 | TTK (0.71) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL525791 | 0.90 | TTK (0.71) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL12473974 | 0.90 | TTK (0.72) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL12473975 | 0.90 | TTK (0.72) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL14990366 | 0.86 | TTK (0.83) | TTKEIF2AK3IGF1RPTK2AURKA | |
| SCHEMBL14990540 | 0.85 | TTK (1.00) | TTKEIF2AK3PIM1PIM2IGF1R | |
| SCHEMBL526356 | 0.85 | TTK (1.00) | TTKEIF2AK3PIM1PIM2IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9333205-B2 | Isoxazolo-quinazolines as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-10 | — | — | US | disclosed |
| EP-2598508-B1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-04-22 | — | — | EP | disclosed |
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |