Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 4/20 | 0.52 |
| ▸ | RPS6KA6 | Q9UK32 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 8/20 | 0.35 |
| ▸ | IDH1 | O75874 | 6/20 | 0.35 |
| ▸ | CDK4 | P11802 | 3/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | CCND2 | P30279 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.34 |
| ▸ | PLK2 | Q9NYY3 | 3/20 | 0.34 |
| ▸ | MARK3 | P27448 | 1/20 | 0.34 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL523785 | 0.93 | BRD4 (0.54) | BRD4RPS6KA6PLK1IDH1CDK4 | |
| SCHEMBL523786 | 0.93 | BRD4 (0.54) | BRD4RPS6KA6PLK1IDH1CDK4 | |
| SCHEMBL20815329 | 0.93 | BRD4 (0.54) | BRD4RPS6KA6PLK1IDH1CDK4 | |
| SCHEMBL523440 | 0.93 | BRD4 (0.54) | BRD4RPS6KA6PLK1IDH1CDK4 | |
| SCHEMBL523203 | 0.87 | BRD4 (0.66) | BRD4PLK1IDH1PLK3PLK2 | |
| SCHEMBL524305 | 0.87 | BRD4 (0.66) | BRD4PLK1IDH1PLK3PLK2 | |
| SCHEMBL524306 | 0.87 | BRD4 (0.66) | BRD4PLK1IDH1PLK3PLK2 | |
| SCHEMBL524048 | 0.85 | BRD4 (0.55) | BRD4RPS6KA6PLK1PLK3PLK2 | |
| SCHEMBL20815288 | 0.85 | BRD4 (0.55) | BRD4RPS6KA6PLK1PLK3PLK2 | |
| SCHEMBL522804 | 0.85 | BRD4 (0.55) | BRD4RPS6KA6PLK1PLK3PLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8278297-B2 | Protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-10-02 | — | — | US | disclosed |
| US-20120028966-A1 | PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028966-A1 | PROTEIN KINASE INHIBITORS | MAP3K20, MAP3K1, MAP3K6 | BRD4 1038/4885RPS6KA6 105/4885PLK1 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.