Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 9/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 3/20 | 0.37 |
| ▸ | CTSS | P25774 | 3/20 | 0.37 |
| ▸ | CTSK | P43235 | 3/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6755447 | 1.00 | CTSC (0.41) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL6754231 | 1.00 | CTSC (0.41) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL5255993 | 1.00 | CTSC (0.41) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL6840907 | 1.00 | CTSC (0.41) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL5258496 | 0.86 | CTSC (0.55) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL6754236 | 0.86 | CTSC (0.55) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL6755449 | 0.86 | CTSC (0.55) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL6754265 | 0.85 | EPHX1 (0.44) | CTSCKCNH2EPHX1CNR2 | |
| SCHEMBL6755267 | 0.82 | CTSC (0.41) | CTSCKCNH2CTSBCTSSCTSK | |
| SCHEMBL6753554 | 0.81 | CTSC (0.41) | CTSCKCNH2CTSBCTSSCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453801-B1 | SUBSTITUTED 2-AMINO-CYCLOALKANECARBOXAMIDES AND THEIR USE AS CYSTEINE PROTEASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |