Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 20/20 | 0.79 |
| ▸ | FLT3 | P36888 | 16/20 | 0.79 |
| ▸ | KIT | P10721 | 14/20 | 0.79 |
| ▸ | FLT1 | P17948 | 8/20 | 0.67 |
| ▸ | CSF1R | P07333 | 7/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.67 |
| ▸ | TEK | Q02763 | 2/20 | 0.67 |
| ▸ | FLT4 | P35916 | 6/20 | 0.54 |
| ▸ | LCK | P06239 | 5/20 | 0.54 |
| ▸ | BLK | P51451 | 5/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.54 |
| ▸ | AXL | P30530 | 3/20 | 0.54 |
| ▸ | FRK | P42685 | 3/20 | 0.54 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.54 |
| ▸ | HIPK2 | Q9H2X6 | 3/20 | 0.54 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.54 |
| ▸ | MAP4K5 | Q9Y4K4 | 3/20 | 0.54 |
| ▸ | CDK1 | P06493 | 2/20 | 0.54 |
| ▸ | CSNK1G2 | P78368 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394108 | 0.91 | KDR (0.78) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL5253491 | 0.90 | KDR (0.64) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL1380250 | 0.89 | KDR (0.65) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL4740470 | 0.89 | KDR (0.76) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL4740129 | 0.88 | KDR (0.75) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL421372 | 0.88 | KDR (1.00) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL5252618 | 0.85 | KDR (0.60) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL1383935 | 0.83 | KDR (0.62) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL4738177 | 0.82 | KDR (0.64) | KDRFLT3KITFLT1CSF1R | |
| SCHEMBL5249393 | 0.82 | KDR (0.63) | KDRFLT3KITFLT1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |