Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 16/20 | 0.63 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.60 |
| ▸ | GAK | O14976 | 1/20 | 0.60 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.60 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.60 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.60 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.60 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.60 |
| ▸ | STK36 | Q9NRP7 | 1/20 | 0.60 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260841 | 0.88 | MAPK14 (0.60) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL5257192 | 0.82 | MAPK8 (0.67) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL4776423 | 0.80 | MAPK14 (0.63) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL14490863 | 0.79 | MAPK14 (0.55) | MAPK14MAPK8RPS6KA4MAP4K4MAPK9 | |
| SCHEMBL14014987 | 0.78 | MAPK14 (0.66) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL5258493 | 0.77 | MAPK14 (0.58) | MAPK14MAPK8RPS6KA4MAP4K4MAPK9 | |
| SCHEMBL5112287 | 0.76 | MAPK14 (0.82) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| SCHEMBL29594531 | 0.76 | MAPK14 (0.82) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| R-1487 SCHEMBL29527296 | 0.75 | MAPK14 (1.00) | MAPK14MAPK8GAKRPS6KA4PRKD3 | |
| R-1487 SCHEMBL5120612 | 0.75 | MAPK14 (1.00) | MAPK14MAPK8GAKRPS6KA4PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | DEWDNEY NOLAN J | 2007-06-14 | — | — | US | disclosed |
| EP-1620105-B1 | (6-(PHENOXY)-PYRIDO¬3,4-D|PYRIMIDIN-2-YL)-AMINE DERIVATIVES AS P38 KINASE INHIBITORS FOR THE TREATMENT OF INFLAMMATORY CONDITIONS SUCH AS RHEUMATOID ARTHRITIS | HOFFMANN LA ROCHE (CH) | 2007-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135459-A1 | Substituted 7-aza-quinazoline compounds useful as p38 kinase inhibitors | MAPK7, MAPK1, MAPK8 | MAPK14 26/4885MAPK8 3/4885GAK 146/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.