Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | HTR3A | P46098 | 10/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | WNT1 | P04628 | 1/20 | 0.41 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.41 |
| ▸ | HTR3B | O95264 | 1/20 | 0.41 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.41 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2086515 | 0.82 | DYRK1A (0.65) | DYRK1AGSK3BWNT1 | |
| SCHEMBL5247213 | 0.81 | GSK3B (0.44) | DYRK1AGSK3BHTR3AMEN1KMT2A | |
| SCHEMBL2089776 | 0.80 | DYRK1A (0.76) | DYRK1AGSK3BWNT1 | |
| SCHEMBL5252333 | 0.74 | GSK3B (0.48) | DYRK1AGSK3BHTR3AMEN1KMT2A | |
| SCHEMBL2088104 | 0.73 | DYRK1A (0.69) | DYRK1AGSK3BHTR3AWNT1 | |
| SCHEMBL2088885 | 0.72 | DYRK1A (0.61) | DYRK1AGSK3BMEN1KMT2AALDH1A1 | |
| SCHEMBL2088319 | 0.71 | DYRK1A (0.77) | DYRK1AGSK3BWNT1 | |
| SCHEMBL2086993 | 0.70 | DYRK1A (0.72) | DYRK1AGSK3BWNT1 | |
| SCHEMBL7506894 | 0.69 | DYRK1A (0.64) | DYRK1AGSK3BHTR3AWNT1HTR3E | |
| SCHEMBL7364907 | 0.69 | DYRK1A (0.64) | DYRK1AGSK3BHTR3AWNT1HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742944-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | Memory Pharmaceuticals Corporation (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2006001894-A1 | INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, 1,2-BENZOISOTHIAZOLES, AND PREPARATION AND USES THEREOF | MEMORY PHARMACEUTICAL CORPORATION (US) | 2006-01-05 | — | — | WO | disclosed |