Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.61 |
| ▸ | AURKA | O14965 | 6/20 | 0.61 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.56 |
| ▸ | CDK4 | P11802 | 6/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 6/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.52 |
| ▸ | CCND1 | P24385 | 2/20 | 0.52 |
| ▸ | CDK9 | P50750 | 2/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | BUB1 | O43683 | 1/20 | 0.52 |
| ▸ | ULK1 | O75385 | 1/20 | 0.52 |
| ▸ | STK16 | O75716 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | LATS1 | O95835 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 1/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL525843 | 0.84 | CDK2 (0.62) | CDK2AURKACCNA2CCNA1CDK4 | |
| SCHEMBL4169115 | 0.76 | CDK2 (1.00) | CDK2AURKACCNA2CCNA1CDK4 | |
| SCHEMBL525755 | 0.73 | CDK2 (0.61) | CDK2AURKACCNA2CCNA1CDK4 | |
| SCHEMBL525844 | 0.72 | CDK2 (0.60) | CDK2AURKACCNA2CCNA1CDK4 | |
| SCHEMBL13852057 | 0.70 | CDK2 (0.85) | CDK2AURKACCNA2CCNA1CDK4 | |
| Potassium SCHEMBL4155030 | 0.69 | CDK2 (0.84) | CDK2AURKACCNA2CCNA1CDK4 | |
| SCHEMBL4155017 | 0.69 | CDK2 (0.84) | CDK2AURKACCNA2CCNA1CDK4 | |
| Milciclib SCHEMBL619139 | 0.68 | CDK2 (1.00) | CDK2AURKACCNA2CCNA1CDK4 | |
| Potassium Ion SCHEMBL4155023 | 0.68 | CDK2 (0.82) | CDK2AURKACCNA2CCNA1CDK4 | |
| Potassium Ion SCHEMBL31326946 | 0.68 | CDK2 (0.82) | CDK2AURKACCNA2CCNA1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |