Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | MBTD1 | Q05BQ5 | 2/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1779679 | 0.91 | HRH3 (0.45) | L3MBTL3L3MBTL1HRH3MBTD1OPRK1 | |
| SCHEMBL3621738 | 0.88 | HRH3 (0.51) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1744762 | 0.88 | HRH3 (0.49) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1466003 | 0.87 | AKR1C3 (0.50) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL25196498 | 0.87 | GRIN2D (0.46) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL29351375 | 0.87 | GRIN2D (0.46) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL2324509 | 0.84 | HRH3 (0.47) | L3MBTL3L3MBTL1HRH3GRIN2DGRIN3B | |
| SCHEMBL2255519 | 0.83 | GRIN2D (0.56) | L3MBTL1GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL4122718 | 0.81 | HRH3 (0.42) | HRH3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3573336 | 0.81 | GRIN2D (0.54) | L3MBTL1GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | disclosed |