Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 3/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | CDK4 | P11802 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10092919 | 0.95 | CHEK1 (0.38) | CHEK1ABL1TNIKEGFRCCNC | |
| SCHEMBL10220029 | 0.78 | CDK2 (0.42) | CHEK1ABL1EGFRCCNCCDK8 | |
| Trifluoroacetic Acid SCHEMBL14990435 | 0.78 | CCNA2 (0.45) | PIM1FLT3CDK4KITAURKA | |
| SCHEMBL9940549 | 0.77 | CCNC (0.38) | CHEK1ABL1TNIKEGFRCCNC | |
| Trifluoroacetic Acid SCHEMBL11021468 | 0.76 | PLK1 (0.41) | C1SPIM1PIM3FLT3CDK4 | |
| SCHEMBL9940573 | 0.75 | PLK1 (0.41) | CHEK1EGFRCCNCCDK8LRRK2 | |
| Trifluoroacetic Acid SCHEMBL9938040 | 0.73 | PLK1 (0.44) | FLT3KITCCNA2CDK2PLK1 | |
| Trifluoroacetic Acid SCHEMBL9937563 | 0.72 | PLK1 (0.43) | FLT3KITCCNA2CDK2PLK1 | |
| Trifluoroacetic Acid SCHEMBL9937628 | 0.72 | PLK1 (0.45) | PIM1FLT3KITCCNA2CDK2 | |
| SCHEMBL526265 | 0.72 | CDK2 (0.49) | PIM1FLT3CDK4KITAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9333205-B2 | Isoxazolo-quinazolines as modulators of protein kinase activity | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2016-05-10 | — | — | US | disclosed |
| EP-2598508-B1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES SRL (IT) | 2015-04-22 | — | — | EP | disclosed |
| US-20130143896-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2013-06-06 | — | — | US | disclosed |
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143896-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | CSNK1A1, RPS6KA1, CSNK2A1 | C1S 4873/4885CHEK1 501/4885ABL1 114/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.