Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 20/20 | 0.78 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.60 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.60 |
| ▸ | ABL1 | P00519 | 1/20 | 0.57 |
| ▸ | BCR | P11274 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5255736 | 0.92 | SRC (0.77) | SRCEGFRFYNMAP2K1 | |
| SCHEMBL3219384 | 0.88 | SRC (1.00) | SRCEGFRFYNMAP2K1ABL1 | |
| SCHEMBL3229833 | 0.87 | SRC (1.00) | SRCEGFRFYNMAP2K1 | |
| SCHEMBL5255620 | 0.87 | SRC (0.76) | SRCEGFRFYNMAP2K1 | |
| SCHEMBL5258555 | 0.83 | SRC (0.76) | SRCEGFRFYNMAP2K1 | |
| SCHEMBL6184537 | 0.81 | SRC (0.65) | SRCEGFRFYNMAP2K1ABL1 | |
| SCHEMBL5256421 | 0.81 | SRC (0.72) | SRCEGFRFYNMAP2K1ABL1 | |
| SCHEMBL3230437 | 0.81 | SRC (1.00) | SRCEGFRFYNMAP2K1 | |
| SCHEMBL3228183 | 0.80 | SRC (1.00) | SRCEGFRFYNMAP2K1 | |
| SCHEMBL3230024 | 0.80 | SRC (1.00) | SRCEGFRFYNMAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | claimed |