Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 4/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5187989 | 0.80 | PLK1 (0.43) | PLK1CSNK2A1PLK3ELANE | |
| SCHEMBL20558012 | 0.79 | ELANE (0.36) | PLK1CSNK2A1PLK3ELANEKMT2A | |
| SCHEMBL28877850 | 0.78 | NAMPT (0.46) | PLK1CSNK2A1PLK3ELANENAMPT | |
| SCHEMBL4697047 | 0.74 | ELANE (0.34) | ELANECREBBPBRD4HTT | |
| SCHEMBL5260866 | 0.70 | CHRM2 (0.31) | — | |
| SCHEMBL5260871 | 0.70 | CHRM2 (0.31) | — | |
| SCHEMBL22980483 | 0.70 | PLK1 (0.79) | PLK1CSNK2A1PLK3HTR2AHTR2C | |
| SCHEMBL20986752 | 0.69 | PLK1 (0.35) | PLK1CSNK2A1PLK3HTR2AHTR2C | |
| SCHEMBL23387868 | 0.68 | PDK2 (0.43) | PLK1CSNK2A1PLK3NAMPTCREBBP | |
| SCHEMBL3142557 | 0.67 | PLK1 (0.93) | PLK1CSNK2A1PLK3HTR2AELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1798231-A2 | Intermediate products for the preparation of antibacterial compounds | NOVEXEL (FR) | 2007-06-20 | — | — | EP | disclosed |
| EP-1399444-B1 | NOVEL HETEROCYCLIC COMPOUNDS, METHOD FOR PREPARING SAME AND USE THEREOF AS MEDICINES, IN PARTICULAR AS ANTI-BACTERIAL AGENTS | NOVEXEL (FR) | 2007-04-11 | — | — | EP | disclosed |