Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.30 |
| ▸ | HTT | P42858 | 2/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15386622 | 0.96 | KMT2A (0.37) | HCAR2ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL526385 | 0.76 | BRD4 (0.48) | ALDH1A1KDM4EPOLBRXFP1KMT2A | |
| SCHEMBL3590392 | 0.73 | SMN1; SMN2 (0.50) | HCAR2ALDH1A1KDM4EPOLBKMT2A | |
| SCHEMBL12499170 | 0.73 | NPC1 (0.31) | KMT2AHPGDRAB9AHTTNPC1 | |
| SCHEMBL12499167 | 0.73 | NPC1 (0.31) | KMT2AHPGDRAB9AHTTNPC1 | |
| SCHEMBL525750 | 0.73 | HCAR2 (0.40) | HCAR2ALDH1A1KDM4EPOLBRXFP1 | |
| SCHEMBL12498389 | 0.73 | BRD4 (0.45) | ALDH1A1KDM4EKMT2AHPGDMEN1 | |
| SCHEMBL849074 | 0.66 | CYP1A2 (0.48) | HCAR2ALDH1A1KDM4EPOLBRXFP1 | |
| SCHEMBL28322301 | 0.63 | POLB (0.42) | HCAR2ALDH1A1KDM4EPOLBRXFP1 | |
| SCHEMBL846899 | 0.62 | CYP1A2 (0.48) | HCAR2ALDH1A1POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598508-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | Nerviano Medical Sciences S.r.l. (IT) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012013557-A1 | ISOXAZOLO-QUINAZOLINES AS MODULATORS OF PROTEIN KINASE ACTIVITY | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2012-02-02 | — | — | WO | disclosed |