SCHEMBL526074

SCHEMBL526074

Cc1nc2c(F)cccc2c(=O)[nH]1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 12/20 0.70
KDM4E B2RXH2 3/20 0.66
CYP1A2 P05177 1/20 0.66
CYP2D6 P10635 1/20 0.66
CYP2C9 P11712 1/20 0.66
CYP2C19 P33261 1/20 0.66
TNKS2 Q9H2K2 6/20 0.54
TNKS O95271 5/20 0.53
PARP2 Q9UGN5 2/20 0.49
NPC1 O15118 2/20 0.46
ALDH1A1 P00352 2/20 0.46
MAPT P10636 2/20 0.46
RAB9A P51151 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
USP2 O75604 1/20 0.46
GLA P06280 1/20 0.46
GAA P10253 1/20 0.46
HPGD P15428 1/20 0.46
ADORA3 P0DMS8 1/20 0.46
TYMS P04818 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1387263 0.82 PARP1 (1.00) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL29829762 0.80 PARP1 (0.66) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL3507122 0.80 PARP1 (0.66) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL6931033 0.79 PARP1 (0.70) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL577862 0.79 PARP1 (0.51) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL30900892 0.79 PARP1 (0.70) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL215530 0.79 PARP1 (1.00) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL29529679 0.79 PARP1 (1.00) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL15840543 0.79 PARP1 (1.00) PARP1KDM4ECYP1A2CYP2D6CYP2C9
SCHEMBL20404387 0.79 PARP1 (0.64) PARP1KDM4ECYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2935246-B1 ISOQUINOLINONE OR QUINAZOLINONE PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS GILEAD CALISTOGA LLC (US) 2018-07-25 EP disclosed
EP-3008053-B1 PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS GILEAD CALISTOGA LLC (US) 2018-03-21 EP disclosed
WO-2013050527-A1 QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2013-04-11 WO disclosed
WO-2013050527-A1 QUINAZOLINE DERIVATIVES AS PDE10A ENZYME INHIBITORS H. LUNDBECK A/S (DK) 2013-04-11 WO disclosed
WO-2012014109-A1 HETEROCYCLIC SULFONAMIDES AS INHIBITORS OF TRANSFER RNA SYNTHETASE FOR USE AS ANTIBACTERIAL AGENTS RANBAXY LABORATORIES LIMITED (IN) 2012-02-02 WO disclosed