Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.64 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34462756 | 1.00 | AURKA (0.64) | AURKAEPHB4IRAK4CDK4CDK2 | |
| SCHEMBL15492037 | 0.79 | AURKA (0.53) | AURKAEPHB4SYKKMT2ATSHR | |
| SCHEMBL27897793 | 0.79 | AURKA (0.64) | AURKAEPHB4IRAK4CDK4CDK2 | |
| SCHEMBL15489512 | 0.76 | MAPK10 (0.57) | EPHB4CDK2SYKEGFRLRRK2 | |
| SCHEMBL15489626 | 0.76 | AURKA (0.51) | AURKACDK2SYKMEN1MAPT | |
| SCHEMBL18386772 | 0.76 | MAPK8 (0.55) | AURKASYKMEN1MAPTKMT2A | |
| SCHEMBL12813310 | 0.76 | AURKA (0.61) | AURKAEPHB4CDK4CDK2SYK | |
| SCHEMBL15489547 | 0.76 | AURKA (0.51) | AURKACDK4CDK2SYKMEN1 | |
| SCHEMBL18387036 | 0.76 | MAPK10 (0.57) | AURKASYKMEN1MAPTKMT2A | |
| SCHEMBL3947897 | 0.76 | MEN1 (0.66) | AURKAIRAK4FLT1FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9597329-B2 | Aurora kinase inhibitors and methods of making and using thereof | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC (US) | 2017-03-21 | — | — | US | disclosed |
| US-20170000787-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2017-01-05 | — | — | US | disclosed |
| US-9249124-B2 | Aurora kinase inhibitors and methods of making and using thereof | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2016-02-02 | — | — | US | disclosed |
| US-20140057913-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2014-02-27 | — | — | US | disclosed |
| EP-1272477-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| US-7176212-B2 | 2,4-diamino pyrimidine compounds having anti-cell proliferative activity | ASTRAZENECA AB (SE) | 2007-02-13 | — | — | US | disclosed |
| US-7153964-B2 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2006-12-26 | — | — | US | disclosed |
| EP-1107957-B1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2006-10-18 | — | — | EP | disclosed |
| US-20050090493-A1 | 2,4-Diamino pyrimidine compounds having anti-cell proliferative activity | ASTRAZENECA AB | 2005-04-28 | — | — | US | disclosed |
| US-20030149064-A1 | Pyrimidine compounds | ASTRAZENECA AB (SE) | 2003-08-07 | — | — | US | disclosed |
| EP-1272477-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001064654-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2001-09-07 | — | — | WO | disclosed |
| EP-1107957-A1 | PYRIMIDINE COMPOUNDS | AstraZeneca AB (SE) | 2001-06-20 | — | — | EP | disclosed |
| WO-2000012485-A1 | PYRIMIDINE COMPOUNDS | ASTRAZENECA AB (SE) | 2000-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140057913-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | AURKC, AURKA, AURKB | AURKA 2/4885EPHB4 1755/4885IRAK4 1113/4885 |
| US-20050090493-A1 | 2,4-Diamino pyrimidine compounds having anti-cell proliferative activity | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, H1-3, H1-0 | AURKA 345/4885EPHB4 3658/4885IRAK4 4711/4885 |
| US-20030149064-A1 | Pyrimidine compounds | CDK2, CCNI, CCNY | AURKA 72/4885EPHB4 3797/4885IRAK4 2870/4885 |
| US-20170000787-A1 | AURORA KINASE INHIBITORS AND METHODS OF MAKING AND USING THEREOF | AURKC, AURKA, AURKB | AURKA 2/4885EPHB4 1755/4885IRAK4 1113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.