SCHEMBL5260899

SCHEMBL5260899

NCC(=O)N1CCC(c2ccc(NC(=O)C(F)(F)F)c(C3=CCCCC3)c2)CC1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSF1R P07333 18/20 0.54
KIT P10721 6/20 0.54
CYP3A4 P08684 9/20 0.52
BMPR1B O00238 2/20 0.52
PLK4 O00444 2/20 0.52
STK25 O00506 2/20 0.52
RIOK3 O14730 2/20 0.52
CHEK1 O14757 2/20 0.52
GAK O14976 2/20 0.52
DCLK1 O15075 2/20 0.52
MUSK O15146 2/20 0.52
EPHB6 O15197 2/20 0.52
PDPK1 O15530 2/20 0.52
MAP3K13 O43283 2/20 0.52
DAPK3 O43293 2/20 0.52
MAP3K7 O43318 2/20 0.52
NUAK1 O60285 2/20 0.52
JAK2 O60674 2/20 0.52
ULK1 O75385 2/20 0.52
ERN1 O75460 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2913489 0.90 CSF1R (0.67) CSF1RKITCYP3A4BMPR1BPLK4
SCHEMBL3173780 0.89 CSF1R (0.65) CSF1RKITCYP3A4BMPR1BPLK4
SCHEMBL3173704 0.89 CSF1R (0.64) CSF1RKITCYP3A4BMPR1BPLK4
SCHEMBL2913264 0.87 CSF1R (0.66) CSF1RKITCYP3A4BMPR1BPLK4
SCHEMBL2913991 0.86 CSF1R (0.65) CSF1RKITCYP3A4BMPR1BPLK4
SCHEMBL2910690 0.86 CSF1R (0.67) CSF1RKITCYP3A4BMPR1BPLK4
SCHEMBL2913128 0.85 CSF1R (0.64) CSF1RKITCYP3A4BMPR1BPLK4
SCHEMBL3086038 0.84 CSF1R (0.63) CSF1RKITCYP3A4NTRK1LCK
SCHEMBL2910165 0.84 CSF1R (0.69) CSF1RKITCYP3A4BMPR1BPLK4
Trifluoroacetic Acid SCHEMBL2944189 0.84 CSF1R (0.45) CSF1RKITCYP3A4BMPR1BPLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1807077-A2 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA N.V. (BE) 2007-07-18 EP disclosed
WO-2006047277-A2 INHIBITORS OF C-FMS KINASE JANSSEN PHARMACEUTICA, N.V. (BE) 2006-05-04 WO disclosed