Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 17/20 | 0.70 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.58 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.57 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL357051 | 1.00 | PIK3CD (0.70) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG | |
| SCHEMBL357142 | 0.92 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG | |
| SCHEMBL356082 | 0.91 | PIK3CD (0.79) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG | |
| SCHEMBL356081 | 0.91 | PIK3CD (0.79) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG | |
| SCHEMBL355968 | 0.91 | PIK3CD (0.61) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG | |
| SCHEMBL356736 | 0.90 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3R1PIK3CG | |
| SCHEMBL5258074 | 0.90 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3R1PIK3CG | |
| SCHEMBL356188 | 0.89 | PIK3CD (0.69) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG | |
| SCHEMBL16677775 | 0.85 | PIK3CD (0.57) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG | |
| SCHEMBL16677160 | 0.85 | PIK3CD (0.57) | PIK3CDPIK3CBPIK3R2PIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1761540-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2007-03-14 | — | — | EP | claimed |
| WO-2005113556-A1 | QUINAZOLINONES AS INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION (US) | 2005-12-01 | — | — | WO | claimed |