Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 15/20 | 0.62 |
| ▸ | KDR | P35968 | 13/20 | 0.62 |
| ▸ | YES1 | P07947 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.52 |
| ▸ | AURKA | O14965 | 5/20 | 0.52 |
| ▸ | TPX2 | Q9ULW0 | 5/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264078 | 1.00 | TEK (0.62) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL5264046 | 0.93 | TEK (0.62) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL1265075 | 0.93 | TEK (0.62) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL1265559 | 0.93 | TEK (0.67) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL12894949 | 0.93 | TEK (0.67) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL5261502 | 0.93 | TEK (0.67) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL1268630 | 0.91 | TEK (0.63) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL2294037 | 0.88 | TEK (0.54) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL5262311 | 0.88 | TEK (0.54) | TEKKDRYES1AURKBAURKA | |
| SCHEMBL2299347 | 0.88 | TEK (0.52) | TEKKDRYES1AURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113494-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2005-12-01 | — | — | WO | claimed |