Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260943 | 0.94 | PDE5A (0.41) | PDE5AADORA2AADORA2B | |
| SCHEMBL5264617 | 0.92 | PDE5A (0.40) | PDE5AADORA2AADORA2B | |
| SCHEMBL5830512 | 0.91 | PDE5A (0.43) | PDE5AADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL5260459 | 0.91 | PDE5A (0.39) | PDE5A | |
| SCHEMBL5259471 | 0.89 | PDE5A (0.54) | PDE5A | |
| SCHEMBL5830413 | 0.89 | PDE5A (0.52) | PDE5AADORA2AADORA2B | |
| SCHEMBL5265562 | 0.88 | PDE5A (0.48) | PDE5A | |
| SCHEMBL5261002 | 0.88 | CA12 (0.40) | PDE5AADORA2B | |
| SCHEMBL5830712 | 0.88 | PDE5A (0.46) | PDE5A | |
| SCHEMBL5261074 | 0.88 | PDE5A (0.36) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307458-B1 | PYRROLOTRIAZOLOPYRIMIDINONE DERIVATIVES | ALMIRALL LAB (ES) | 2007-10-03 | — | — | EP | disclosed |