SCHEMBL5261889

SCHEMBL5261889

CCC(C(=O)NCCOC)N1CCC(N(CC(N)=O)S(=O)(=O)c2ccc3cc(Cl)ccc3c2)C1=O

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.63
F2 P00734 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5224002 0.92 F10 (0.72) F10F2
SCHEMBL5261178 0.91 F10 (0.65) F10F2
SCHEMBL5261615 0.88 F10 (0.66) F10F2
SCHEMBL5261413 0.86 F10 (0.61) F10F2
SCHEMBL5257233 0.86 F10 (0.61) F10F2
SCHEMBL5226232 0.81 F10 (0.74) F10
SCHEMBL4870635 0.80 F10 (0.66) F10F2
SCHEMBL5224489 0.80 F10 (0.75) F10
SCHEMBL4483756 0.80 F10 (0.78) F10F2
SCHEMBL5228475 0.79 F10 (0.78) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1444201-B1 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS GLAXO GROUP LTD (GB) 2007-09-12 EP disclosed
EP-1444201-A1 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS GLAXO GROUP LIMITED (GB) 2004-08-11 EP disclosed
WO-2003043981-A1 2-(3-SULFONYLAMINO-2-OXOPYRROLIDIN-1-YL)PROPANAMIDES AS FACTOR XA INHIBITORS GLAXO GROUP LIMITED (GB) 2003-05-30 WO disclosed