Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 20/20 | 0.52 |
| ▸ | PDE6C | P51160 | 2/20 | 0.51 |
| ▸ | PDE6D | O43924 | 1/20 | 0.51 |
| ▸ | PDE6A | P16499 | 1/20 | 0.51 |
| ▸ | PDE6G | P18545 | 1/20 | 0.51 |
| ▸ | PDE6B | P35913 | 1/20 | 0.51 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.51 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5260296 | 0.97 | PDE5A (0.55) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5261816 | 0.92 | PDE5A (0.51) | PDE5APDE6CPDE11A | |
| SCHEMBL5831150 | 0.92 | PDE5A (0.57) | PDE5A | |
| SCHEMBL5830458 | 0.92 | PDE5A (0.53) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5261563 | 0.91 | PDE5A (0.52) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5261393 | 0.91 | PDE5A (0.47) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5829824 | 0.90 | PDE5A (0.49) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5259436 | 0.90 | PDE5A (0.54) | PDE5APDE6CPDE6DPDE6APDE6G | |
| SCHEMBL5259471 | 0.89 | PDE5A (0.54) | PDE5APDE6CPDE11A | |
| SCHEMBL5830642 | 0.89 | PDE5A (0.47) | PDE5APDE6CPDE6DPDE6APDE6G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307458-B1 | PYRROLOTRIAZOLOPYRIMIDINONE DERIVATIVES | ALMIRALL LAB (ES) | 2007-10-03 | — | — | EP | disclosed |
| US-7060824-B2 | Pyrrolotriazolopyrimidinone derivatives | ALMIRALL PRODESFARMA, S.A. (ES) | 2006-06-13 | — | — | US | disclosed |