Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.69 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.64 |
| ▸ | DRD3 | P35462 | 10/20 | 0.60 |
| ▸ | DRD2 | P14416 | 8/20 | 0.60 |
| ▸ | LTA4H | P09960 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673646 | 0.91 | DRD3 (0.64) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL31207849 | 0.90 | PDGFRB (0.74) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL16599544 | 0.90 | PDGFRB (0.74) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL3884146 | 0.87 | FLT3 (0.71) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL27219357 | 0.82 | HRH3 (0.67) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL7879688 | 0.81 | FLT3 (0.60) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL3035497 | 0.80 | KDM4E (0.52) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL7879689 | 0.80 | FLT3 (0.59) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL13460613 | 0.80 | PDGFRB (0.77) | FLT3PDGFRBPDGFRADRD3DRD2 | |
| SCHEMBL30193808 | 0.80 | MAOB (0.60) | FLT3PDGFRBPDGFRADRD3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841762-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | Aventis Pharma S.A. (FR) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006061493-A1 | SUBSTITUTED INDOLES, COMPOSITIONS CONTAINING THEM, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE | AVENTIS PHARMA S.A. (FR) | 2006-06-15 | — | — | WO | disclosed |