Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 7/20 | 0.48 |
| ▸ | KDR | P35968 | 6/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1265637 | 0.77 | KDR (0.62) | TEKKDRPDE10AHTT | |
| SCHEMBL1265217 | 0.77 | KDR (0.59) | TEKKDRPDE10AHTTLMNA | |
| SCHEMBL1264516 | 0.76 | TEK (0.56) | TEKKDRPDE10A | |
| SCHEMBL1266363 | 0.75 | TEK (0.67) | TEKKDR | |
| SCHEMBL5264038 | 0.75 | PDE10A (0.51) | TEKKDRPDE10AKMT2A | |
| SCHEMBL1263742 | 0.73 | PDE10A (0.62) | TEKKDRPDE10A | |
| SCHEMBL30143171 | 0.73 | PDE10A (0.59) | TEKKDRPDE10A | |
| SCHEMBL27634795 | 0.72 | JAK2 (0.56) | HTTKMT2AJAK2TYK2ALDH1A1 | |
| SCHEMBL1265623 | 0.72 | KDR (0.60) | TEKKDRPDE10AHTTKMT2A | |
| SCHEMBL5262888 | 0.72 | PDE10A (0.48) | TEKKDRPDE10AKMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113494-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2005-12-01 | — | — | WO | claimed |