Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4468196 | 0.88 | PDE10A (0.36) | PDE10ATSHRMAPTTP53CYP1A2 | |
| SCHEMBL4479508 | 0.83 | TSHR (0.35) | PDE10ATSHRTP53POLBRECQL | |
| SCHEMBL5847322 | 0.78 | TSHR (0.33) | PDE10ATSHRRECQL | |
| SCHEMBL4467311 | 0.77 | TSHR (0.37) | PDE10ATSHRMAPTTP53POLB | |
| SCHEMBL4466488 | 0.76 | POLB (0.35) | PDE10ATSHRMAPTTP53POLB | |
| SCHEMBL4475640 | 0.76 | TSHR (0.36) | PDE10ATSHRMAPTTP53POLB | |
| SCHEMBL4477050 | 0.76 | TSHR (0.34) | PDE10ATSHRTP53POLB | |
| Hydrochloric Acid SCHEMBL4477492 | 0.76 | TSHR (0.36) | PDE10ATSHRMAPTTP53POLB | |
| SCHEMBL4477709 | 0.75 | TSHR (0.36) | TSHRMAPTTP53POLBRECQL | |
| SCHEMBL4474149 | 0.75 | TSHR (0.35) | PDE10ATSHRTP53POLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781662-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | Pfizer, Inc. (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018725-A1 | INHIBITORS OF HEPATITIS C VIRUS RNA-DEPENDENT RNA POLYMERASE, AND COMPOSITIONS AND TREATMENTS USING THE SAME | PFIZER INC. (US) | 2006-02-23 | — | — | WO | disclosed |