Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | UBE2N | P61088 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4053623 | 0.91 | PDE4B (0.45) | PDE4BSMN1; SMN2LMNAMEN1HTT | |
| SCHEMBL4053547 | 0.84 | PDE4B (0.56) | PDE4BALDH1A1KDM4EMAPTNPSR1 | |
| SCHEMBL4052589 | 0.84 | PDE4B (0.43) | PDE4BMAPTSMN1; SMN2LMNAMEN1 | |
| SCHEMBL4055308 | 0.84 | PDE4B (0.47) | PDE4BKDM4ESMN1; SMN2LMNAMEN1 | |
| SCHEMBL4050022 | 0.83 | GAA (0.44) | PDE4BALDH1A1KDM4EMAPTLMNA | |
| SCHEMBL4049916 | 0.83 | PDE4B (0.43) | PDE4BSMN1; SMN2LMNAHTTTBXAS1 | |
| SCHEMBL4049469 | 0.82 | PDE4B (0.48) | PDE4BKDM4EMAPTSMN1; SMN2LMNA | |
| SCHEMBL4048502 | 0.82 | PDE4B (0.45) | PDE4BSMN1; SMN2LMNAHTTTBXAS1 | |
| SCHEMBL4059635 | 0.81 | PDE4B (0.43) | PDE4BSMN1; SMN2LMNAHTTPDE4A | |
| SCHEMBL4055629 | 0.80 | PDE4B (0.44) | PDE4BALDH1A1MAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781621-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2007-05-09 | — | — | EP | claimed |
| WO-2005123693-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | claimed |