SCHEMBL5263248

SCHEMBL5263248

O=c1ccc2cnc(Nc3ccc(-n4cccc4)cc3)nc2n1-c1ccccc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 18/20 0.80
CCND1 P24385 18/20 0.80
CCND2 P30279 18/20 0.80
CCND3 P30281 18/20 0.80
FGFR1 P11362 4/20 0.53
CCNA2 P20248 4/20 0.53
FGFR2 P21802 4/20 0.53
FGFR4 P22455 4/20 0.53
FGFR3 P22607 4/20 0.53
CDK2 P24941 4/20 0.53
CCNB2 O95067 3/20 0.53
CCNE2 O96020 3/20 0.53
CDK1 P06493 3/20 0.53
CCNB1 P14635 3/20 0.53
CCNE1 P24864 3/20 0.53
CCNA1 P78396 3/20 0.53
CCNB3 Q8WWL7 3/20 0.53
SRC P12931 1/20 0.53
MEN1 O00255 1/20 0.49
ALDH1A1 P00352 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5262825 0.89 CDK4 (1.00) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5265462 0.86 CDK4 (0.83) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5262847 0.84 CDK4 (0.73) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5268237 0.84 CDK4 (0.82) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5263279 0.83 CDK4 (0.81) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5263388 0.83 CDK4 (0.78) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5264568 0.81 CDK4 (0.78) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL1890597 0.81 CDK4 (1.00) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL5264618 0.81 CDK4 (0.71) CDK4CCND1CCND2CCND3FGFR1
SCHEMBL4716393 0.81 CDK4 (1.00) CDK4CCND1CCND2CCND3FGFR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1806348-A2 Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation Warner-Lambert Company LLC (US) 2007-07-11 EP claimed
US-6498163-B1 POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS WARNER-LAMBERT COMPANY 2002-12-24 US claimed
EP-0964864-A2 PYRIDO 2,3-D] PYRIMIDINES AND 4-AMINOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1999-12-22 EP claimed
WO-1998033798-A2 PYRIDO[2,3-D]PYRIMIDINES AND 4-AMINO-PYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION WARNER LAMBERT COMPANY (US) 1998-08-06 WO claimed
EP-1806348-A2 Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation Warner-Lambert Company LLC (US) 2007-07-11 EP disclosed
US-6498163-B1 POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS WARNER-LAMBERT COMPANY 2002-12-24 US disclosed
EP-0964864-A2 PYRIDO 2,3-D] PYRIMIDINES AND 4-AMINOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION WARNER-LAMBERT COMPANY (US) 1999-12-22 EP disclosed
WO-1998033798-A2 PYRIDO[2,3-D]PYRIMIDINES AND 4-AMINO-PYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION WARNER LAMBERT COMPANY (US) 1998-08-06 WO disclosed