Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 19/20 | 0.60 |
| ▸ | CCND1 | P24385 | 19/20 | 0.60 |
| ▸ | CCND2 | P30279 | 19/20 | 0.60 |
| ▸ | CCND3 | P30281 | 19/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.54 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.54 |
| ▸ | CDK2 | P24941 | 4/20 | 0.54 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.49 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.49 |
| ▸ | CDK1 | P06493 | 3/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.49 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.49 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.49 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5265347 | 0.88 | CDK4 (0.64) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5263404 | 0.86 | JAK3 (0.51) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5266146 | 0.86 | CDK4 (0.60) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5264006 | 0.85 | CDK4 (0.67) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5263044 | 0.85 | CDK4 (0.68) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5268444 | 0.81 | CDK4 (0.61) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5267656 | 0.79 | CDK4 (0.64) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5263601 | 0.79 | CDK4 (0.50) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5266140 | 0.78 | CDK4 (0.67) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5267894 | 0.77 | CDK4 (0.75) | CDK4CCND1CCND2CCND3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1806348-A2 | Pyrido (2,3-D)Pyrimidines as inhibitors of cellular proliferation | Warner-Lambert Company LLC (US) | 2007-07-11 | — | — | EP | disclosed |
| US-20040224958-A1 | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | BOOTH RICHARD JOHN (US) | 2004-11-11 | — | — | US | disclosed |
| US-6498163-B1 | POTENT INHIBITORS OF CYCLIN-DEPENDENT KINASES AND GROWTH FACTOR MEDIATED KINASES; CANCER, RESTENOSIS, ATHEROSCLEROSIS | WARNER-LAMBERT COMPANY | 2002-12-24 | — | — | US | disclosed |
| EP-0964864-A2 | PYRIDO 2,3-D] PYRIMIDINES AND 4-AMINOPYRIMIDINES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1999-12-22 | — | — | EP | disclosed |
| WO-1998033798-A2 | PYRIDO[2,3-D]PYRIMIDINES AND 4-AMINO-PYRIMIDINES AS INHIBITORS OF CELL PROLIFERATION | WARNER LAMBERT COMPANY (US) | 1998-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224958-A1 | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | CDK4, CDKL1, CCNT1 | CDK4 1/4885CCND1 23/4885CCND2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.