Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 12/20 | 0.73 |
| ▸ | KDR | P35968 | 10/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.64 |
| ▸ | LCK | P06239 | 3/20 | 0.64 |
| ▸ | BRAF | P15056 | 3/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1264813 | 0.90 | TEK (0.84) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1264543 | 0.90 | TEK (0.78) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1264200 | 0.90 | TEK (0.80) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL3822510 | 0.86 | TEK (0.56) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1263743 | 0.85 | TEK (0.91) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1264888 | 0.85 | TEK (1.00) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1264706 | 0.84 | TEK (0.84) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1264952 | 0.84 | TEK (0.84) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1264246 | 0.83 | TEK (0.86) | TEKKDRMAPK14LCKBRAF | |
| SCHEMBL1265019 | 0.83 | TEK (0.70) | TEKKDRMAPK14LCKBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751136-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2007-02-14 | — | — | EP | claimed |
| WO-2005113494-A2 | NITROGENATED HETEROCYCLIC DERIVATIVES AS PROTEIN KINASE MODULATORS AND USE FOR THE TREATMENT OF ANGIOGENESIS AND CANCER | AMGEN INC. (US) | 2005-12-01 | — | — | WO | claimed |