Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 8/20 | 0.55 |
| ▸ | VEGFA | P15692 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | AR | P10275 | 4/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.38 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.38 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8432193 | 0.78 | AR (0.55) | EPAS1VEGFACYP19A1ARSLC22A12 | |
| SCHEMBL920869 | 0.77 | AR (0.54) | EPAS1VEGFACYP19A1ARFNTA | |
| SCHEMBL4168817 | 0.74 | POLB (0.50) | CYP19A1ARPDE4APDE4BPDE4C | |
| SCHEMBL8379001 | 0.74 | PDE4A (0.54) | EPAS1VEGFACYP19A1ARPDE4A | |
| SCHEMBL27839327 | 0.72 | PDE4A (0.53) | EPAS1VEGFACYP19A1ARPDE4A | |
| SCHEMBL8432101 | 0.72 | AR (0.49) | EPAS1VEGFACYP19A1ARFNTA | |
| SCHEMBL921055 | 0.72 | CYP19A1 (0.56) | EPAS1CYP19A1ARPDE4APDE4B | |
| SCHEMBL16555761 | 0.71 | EPAS1 (1.00) | EPAS1VEGFA | |
| SCHEMBL890666 | 0.71 | GAA (0.58) | EPAS1VEGFACYP19A1ARFNTA | |
| SCHEMBL922800 | 0.71 | EPAS1 (0.47) | EPAS1VEGFACYP19A1ARSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2598483-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | Rigel Pharmaceuticals, Inc. (US) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016217-A1 | AMPK-ACTIVATING HETEROCYCLIC COMPOUNDS AND METHODS FOR USING THE SAME | RIGEL PHARMACEUTICALS, INC. (US) | 2012-02-02 | — | — | WO | disclosed |