Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266153 | 0.86 | CMA1 (0.47) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL16049899 | 0.77 | CMA1 (0.47) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL11444891 | 0.72 | CMA1 (0.49) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL16049922 | 0.71 | CMA1 (0.47) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL31667227 | 0.71 | MEN1 (0.61) | MEN1KMT2ACASP3 | |
| SCHEMBL21092750 | 0.70 | CMA1 (0.53) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL18717737 | 0.69 | GSK3A (0.53) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL11618398 | 0.68 | CMA1 (0.50) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL9376691 | 0.67 | BRD4 (0.46) | CMA1GSK3AGSK3BMAPTALDH1A1 | |
| SCHEMBL18732826 | 0.67 | HTT (0.47) | CMA1GSK3AGSK3BMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833800-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | AstraZeneca AB (SE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006071730-A1 | PYRAZOLONE COMPOUNDS AS METABOTROPIC GLUTAMATE RECEPTOR AGONISTS FOR THE TREATMENT OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS | ASTRAZENECA AB (SE) | 2006-07-06 | — | — | WO | disclosed |