Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 2/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.74 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.74 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.74 |
| ▸ | DRD1 | P21728 | 1/20 | 0.74 |
| ▸ | DRD4 | P21917 | 1/20 | 0.74 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.74 |
| ▸ | HRH2 | P25021 | 1/20 | 0.74 |
| ▸ | TACR1 | P25103 | 1/20 | 0.74 |
| ▸ | PTAFR | P25105 | 1/20 | 0.74 |
| ▸ | HTR2A | P28223 | 1/20 | 0.74 |
| ▸ | HTR2C | P28335 | 1/20 | 0.74 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.74 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.74 |
| ▸ | HTR7 | P34969 | 1/20 | 0.74 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.74 |
| ▸ | DRD3 | P35462 | 1/20 | 0.74 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266092 | 0.97 | GNRHR (0.72) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5265229 | 0.96 | GNRHR (0.76) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5267917 | 0.95 | GNRHR (0.66) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5264167 | 0.93 | CYP2C9 (0.65) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5264407 | 0.93 | GNRHR (0.74) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5267031 | 0.93 | GNRHR (0.73) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5269069 | 0.92 | GNRHR (0.64) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5264963 | 0.91 | GNRHR (0.68) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5265622 | 0.90 | GNRHR (0.69) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 | |
| SCHEMBL5268062 | 0.90 | CYP2C9 (0.67) | GNRHRCYP2C9CACNA1FCHRM4ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648906-B1 | ORGANOSILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | claimed |
| US-20070111967-A1 | Organosilicon compounds and their use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-05-17 | — | — | US | claimed |
| EP-1648906-B1 | ORGANOSILICON COMPOUNDS AND THEIR USE | TAKEDA CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |
| US-20070111967-A1 | Organosilicon compounds and their use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-05-17 | — | — | US | disclosed |
| US-20070111967-A1 | Organosilicon compounds and their use | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070111967-A1 | Organosilicon compounds and their use | CYP2B6, UGT1A6, CYP2D6 | GNRHR 2847/4885CYP2C9 37/4885CACNA1F 4369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.